
Day Two: Deeper Down The Rabbit-Hole.
The Physiology Of Stress
So let’s build on yesterday’s post and ask what is happening at various levels biologically in the body? What is going on? What will help to really understand the physiology of stress?
Today, we’ll look at how the body gets stressed, step by step.
Tomorrow, we will definitely be through the looking glass, and begin looking at moods, emotions, the limbic pathway, and the neuropsychology of stress.
We approach the rabbit hole. Deep breath folk. Ready? Let’s go!
On the first day of the course we saw that proteins called hormones are produced by your glands (Endocrine system). These not only keep your body’s internal environment in balance (Homeostasis) but also can knock it out of balance as a reaction to internal and external counterproductive stress (The HTA axis).

Here we need to switch attention to an overall picture and take into account along with hormones. the real main signaler of what happening in the body: the nervous system, or more accurately, the nervous systems. In addition to the hormones the complex array of nerves throughout the system send signals to the brain and stomach.
The body is dvided into two main nervous systems. The Central Nervous System (CNS) and The Peripheral Nervous Systems (PNS). The one deals with stimuli, the other manages the automatic functions. In banking terms, the front office and back office as it were; the public face and the administration. Without either, like any good organization, the organization will cease to function. CNS and PNS are fine for anatomy. But we want function.
So for function we call the CNS The Somatic Nervous System (SNS) and the PNS The Autonomic Nervous System (ANS).
As their names suggest the somatic deals with bodily movement (Soma=body Gk) stimuli (Skin, eyes (optic nerve), taste etc;). And the autonomic with those responses which are automatic.
You would not want to have to think about making your heart beat, or lungs work etc; but, along when need the heart beat increases or decreases, the stomach works or relaxes the autonomic nervous system (ANS) send the necessary instructions.
The ANS is further divided into three: sympathetic, parasympathetic, and enteric divisions. The enteric system is found in all life with a nervous system and handles the digestive tract.
The Parasympathetic Nervous System (PNS) can be seen at work when we relax, switch off, and calm down. Look for things like smaller pupils, slower breathing, even signs of hunger as it works on the digestive system too.
The human body also has The Sympathetic Nervous System (SNS) that give us, in the famous words of Walter B Cannon in 1915, the fight or flight response. Considering, as we discussed on day one, he also coined the term hoeostasis, you could say he was onto a good thing in terms of the history of medicine.
As we are all too much aware with the fight/flight response the heart rate speeds up, blood pressure increases, adrenalin (epinephrine) from the adrenal glands floods the system and gets our bodies ready for action. At what do we do? We sit still in our office chairs and have a meltdown.
Flight in the shape of a pair of running shoes and an MP3 player is a much better deal.
So, the SNS is our bad boy here. It triggers the limbic pathway, which runs throughout the brain and handles emotions, (More on this on day three), and this in turn releases the Hypothalamus-Pituitary-Andrenalin (HPA axis) reaction (Discussed yesterday) that floods the body with cortisol.
It doesn’t even take, literally, a second to upset us.
Experiments have shown that before the eye can consciously register a bad image, (By flashing for a microsecond a group of photos that would create discomfort in a normal person faster than then the eye can register them), the body at the HPA axis is working. This means it begins to react to danger even before we are truly aware of it. It is one of the biggest problems in the workplace and modern society is that we are constantly stimulating these responses through noise and time demands.
Anyway, the HPA axis combines to releases protein hormones called glucocortisoids from the adrenal gland.
The two most important glucocortisoids are cortisol, (also called hydrocortisone), which is really important to our discussion, and we will return to in detail in a short while and dexamethasone, which is absolutely the saint and good guy here.
Dexamethasone is used to help rheumatoid, cancer, and brain tumors. You may even have had some if you had a bad facial reaction if your wisdom teeth have been taken out. Dexamethasone simply reduces swelling. It can even be used to control the pituary-hypothalamus and reduce cortisol, but this in only currently recommended for extreme measure, such as Cushing’s disease, where the cortisol is out of control and results in growth in the pituatary gland. This is outside the realm of accepted variances for normative stress, and is rare. It can be caused by taking steroids. I am looking at its use as a anti-inflammatory medicine for daily stess and will report back on that, better is to avoid adrenal cortisol overload in the first place. More on that below.

Cortisol

11,17,21-trihydroxy-,(11beta)-
pregn-4-ene-3,20-dione
Cortisol is, in our current understanding, the most important hormone that regulates homeostatis, our inner state.
Now cortisol in moderation is vital for life, without it you die. It stimulates the conversion of proteins to glucose (So foods to energy, for example), raises blood sugar, and promotes glycogen, a super-sized polymer of glucose as it were, which is essential for the liver to function and control metabolism, the release of energy (in conjunction with the thyroid and the hormone, thyroxine).
The liver is the power station then converting the fuel into electricity. It also, with the kidneys, detoxes the body. Obviously, this is all good.
And very, very bad when it’s goes wrong.
If the adrenal gland receives messages from the brain via the pituitary gland to overproduce then the trouble begins.
You may recall that one of our symptoms of stress from yesterday was an enlarged liver or spleen.
In view of what we’ve just said about the liver, let’s make a scientific observations - Oops.
For as the liver regulates the body’s need for energy, and the spleen, produces the lymphocytes, or white cells, necessary to combat disease, we begin to see that stress literally shuts down the body’s immune system. And the handy helper in crime?
Cortisol and the corticosteroids, of course. (Which does sound dangerously like the name of a third year medical school cover band?).
So, first we need to understand, in more detail, how cortisol is produced, and what it normally does. Then we can see what it does to us when it goes haywire. Then we’ll ask what controls are known.
Firstly as we said yesterday all hormone processes start in the brain.
In the hypothalamus, above the brain stem, there lies The Paraventricular Nucleus (PVN). It is small (Well, tiny actually: the brain is absolutely amazing!) area near the optic chiasm.
It contains bundles of neurons, one is called The Magnocellular, and the other, The Parvocellular.
They both produce those protein hormones.
These then move to the pituitary gland.
The magnocellalar produces two hormones, the oxcytocin and vasopressin.
Oxytocin is sometimes called the love/social hormone as it is released when we feel friendly. It is also the neurotransmitter released during sex. (No, I’m not getting into the research parameters on the discovery of that one here either). It is also crucial in neuopsychology for pairing, bondin,g and friendship overtures.
Vasopression, which helps the body retain and dispel water through the kidneys, also contracts blood vessels and caillaries.
Both, when you stop and think about it are important in stress control.
Firstly, we need to look at the more important, for the purposes of toady’s discussion, the parvocellular region.
It produces three main hormones: CRH (Corticotrpin-releasing hormone), and vasopressin. The third, TRH (Thytropin-releasing hormone) that stimulates the thyroid. It is the first two we are interested in.
CRH and vasopressin combine to produce ACTH (Adrenocortiotropic hormone), which we talked about yesterday. ACTH causes the reaction in the pituitary gland that then talks to the adrenal gland, which then responds by releasing cortisol.
So can we do anything about this. Well, firstly, try to restore homeostasis. Highly effective and recommended non-pharmaceutical actions include deep sleep, long walks, calm, calm, calm, breath, and avoid caffeine. Caffiene aggrevates cortisol, which is actually at is strongest surge first thing in the morning. So that early morning cup of coffee is a jolt rather than a help. The cortisol comes in at around 30 minutes after waking, often making us think it’s the coffee.
Alternatively, you can be a woman. This helps enormously.

Professor Shelly E Taylor, UCLA.
Professor Shelly E Taylor, of UCLA, who was awarded the William James Fellow Award in 2001 by the American Psychology Society, and is the author of the marvellous “The Tending Instinct” says “Woman show more often a “tend-befriend” rather fight-flight response”. This can easily be proven: at the end of working day a woman will lose her stress by talking, or getting involved with her close relationships. Men, on the other hand, put on their iron masks and withdraw for as long as it takes, or allowed. Or explode.
There is evidence to suggest that oxytocin (mentioned earlier), which calms us, is negated by male hormones, but amplified by estrogen (the female hormone) meaning woman are born calmer.
Secondly, a visit to a doctor is recommended: missing annual cholesterol and blood pressure checks are a pretty good reason as to why doctors can’t cure people. GO!
Finally, for people showing the physical symptoms of stress a Cort-Stim (Cortrosyn Stimulation) blood test, which tests the adrenal response with an injection of ACTH and looks for an appropriate cortisol response. It’s taken from the elbow or hand, and generally a high-carb diet is recommended the day before followed by six hours of fasting before the test itself.
For most cases, steps one and two are enough.
Now that we have an overview of the biology of stress we are ready to move into the more commonly understood meanings of stress, as both positive in negative, in the moods, emotions,and the limbic pathway and the neuropsychology of that.
Day Three: Yeah Baby, Yeah! Moods, Emotions, the Limbic Pathway and Neuropsychology