Leonardo Da Vinci - View Of A Skull c.1489 (Pen and Ink), Galleria dell’Accademia, Venezia

I spend a lot of time talking at schools about life, money, careers, and yes, health. I know it is next to useless to say to a teenager “Don’t Do Drugs!” - however, show then MRI scans of damage to the hippocampus from ecstasy use, or current statistics of early onset Alzheimer’s in chronic cannabis users, or psychiatric statistics of drug involvement in teenage schizophrenia and manic / depressive behaviour, or finally, amputees testimonies from collapsed veins cutting off circulation and how they just got started with gateway drugs, and yes, you get some interest.

So a little science regarding the incredible dangers of anorexia on the system is justified occasionally. The research lead by Dr Miriam Bredella, and presented at the Radiological Society of North America last weekend is compelling. Bone isn’t just there to hold up the muscle and stop us looking like a big pancake; it is essential for disease management, renewal of red and white blood cells, and for posture.

The damage to looks as well as the immune system is seriously dangerous, and even irreversible. Given that the largest source of fat in the human body is not our behinds but our brains. The body must have fat to survive and grow. It will take it from the last available source: the brain. Teenage brains are plastic; this means they are growing and changing, depriving the brain of its base composite has horrific effects on intelligence, IQ, careers, and emotional lives. Awful. Now we are seeing that the same is true for bone structure.

We need to find a way to get beyond media imaging into pictures of health and that starts with education. Hope it helps.

Children and teenagers with even mild cases of anorexia exhibit abnormal bone structure, according to a new study appearing in the December issue of Radiology and presented at the annual meeting of the Radiological Society of North America (RSNA).

“Adolescence is the most critical period for growth of bone mass, and the onset of anorexia interferes with that process,” said Miriam A. Bredella, M.D., musculoskeletal radiologist at Massachusetts General Hospital and assistant professor of radiology at Harvard Medical School in Boston. “Impairment of bone development may permanently alter bone structure and increase the risk of fractures and osteoporosis in adult life.”

Anorexia is an eating disorder characterized by emaciation, distorted body image and intense fear of gaining weight. People with the disorder are obsessed with weight control and often perceive themselves as overweight, even when they are dangerously thin. The disorder primarily occurs among young women and affects one in 100 adolescent girls, according to the National Women’s Health Information Center.

Among the many health problems associated with anorexia is bone loss. Typically, dual energy x-ray absorptiometry (DXA) is used to test bone mineral density in adolescents with anorexia.

Dr. Bredella and colleagues set out to determine if alterations in bone structure occur before significant decreases in bone mineral density become evident.

The researchers used high-resolution, flat-panel volume computed tomography (CT) and DXA to study 10 adolescent girls, age 13 to 18, with mild anorexia and 10 age-matched girls without the disorder. The new, high-resolution CT exam allowed the researchers to identify differences in bone structure between the patients with anorexia and the healthy controls, whereas bone mineral density measurements obtained using DXA did not.

The results showed that while there was not a significant difference in bone mineral density between the anorexic patients and the healthy control group, there were significant structural differences, indicating that changes in bone structure begin to occur in anorexic patients well before decreases in bone density.

“Our data suggest that reassuring values of bone mineral density obtained using DXA may not reflect the true status of bone structure in this undernourished population,” Dr. Bredella said. “In patients with anorexia, bone structure should be analyzed to detect abnormal bone health. Flat-panel volume CT allows the examination of bone at high resolution with relatively low radiation exposure making it a suitable technique for evaluation of bone structure in adolescent patients.”

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Article adapted by Medical News Today from original press release.
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“Distal Radius in Adolescent Girls with Anorexia Nervosa: Trabecular Structure Analysis with Very High Resolution Flat-Panel Volume CT.” Collaborating with Dr. Bredella on this paper were Madhusmita Misra, M.D., Karen K. Miller, M.D., Ijad Madisch, M.D., Ammar Sarwar, M.D., Arnold Cheung, M.D., Anne Klibanski, M.D., and Rajiv Gupta, M.D., Ph.D.

Yes, this is a blog about the brain and work, but as I was going through the medical sites I cam across this fascinating piece from Oxford University and a team led by Professor Thomas Helleday that hasn’t appeared on Digg or other aggregate sites.

Here is the article by Jonathan Wood from the OxSciBlog site:

A new concept for cancer therapy could lead to treatments personalised to each patient’s tumour without any side effects, says Professor Thomas Helleday, who is pioneering the idea at Oxford University [watch a video describing this work].

He believes cancer may have an ‘Achilles’ heel’: The genetic damage that builds up in cancer cells and the subsequent escape from the body’s normal controls on growth may also make them very susceptible to treatments that block repair of DNA.

‘DNA damage is a prerequisite for most cancers,’ explains Professor Helleday of the Gray Institute for Radiation Oncology and Biology at Oxford University. ‘Whether that damage is a result of the tar in cigarettes, toxins or genetic and environmental factors, it can result in mutations that alter genes. That genetic instability drives cancer.’

Normal cells have many pathways and mechanisms to correct and repair DNA breaks and damage as they occur. These are crucial to maintain the normal functioning of the cell. If the damage is too great, the cells are either killed by a process called apoptosis or their growth and division is arrested so that the damage doesn’t go any further.

Many cancers have defects in one or more repair processes which enables them to sidestep these controls. ‘We can exploit these defects,’ says Professor Helleday. ‘If we can block the remaining repair systems, the body will knock out the cancer cells. Normal cells with a full set of repair kits will be fine.’

Such treatments, designed to each patient’s individual cancer, should mean patients experience few, if any, side effects from the treatment. It would be a great advance over standard chemotherapy techniques which are toxic to all dividing cells.

Professor Helleday’s group have studied defects in the BRCA1 and BRCA2 genes which predispose women to developing breast and ovarian cancer. In these cancers, a pathway that repairs mistakes when DNA is replicated no longer works, and the cancer cells are reliant on a different process based on a protein called PARP for survival.

The researchers showed that these breast and ovarian cancers could be targeted using an existing drug that inhibits the PARP protein. The idea has now been licensed to Astra Zeneca and phase II clinical trials of the drug involving a few hundred patients began in May 2007.

‘The results are better than expected,’ says Professor Helleday. ‘I thought we might see the cancers in these people stop growing. But in many cases the drug is killing off the cancer cells. The tumours have shrunk substantially and the patients report no serious side effects.’

Professor Helleday is sure this can be a general concept for tackling many cancers: ‘If there are two possible pathways for repairing damage and one is lost in a cancer, we can target the second one. This is called synthetic lethality as the drug is not toxic on it own – only for the cancer cells with this extra defect.’

‘In the future, you could imagine screening a patient’s cancer for defects, picking out the precise inhibitors to target the remaining DNA repair pathways, and treat that person’s tumour in a very targeted way.’

‘We know of thousands of these pathways in yeast. We want to extend this knowledge into humans so we can exploit them and come up with selectively toxic therapies with no side effects and no damage to normal tissue,’ he says.

Truly amazing stuff!

It is good to be asked back again.

When the people asking are a branch of the United Nations then it is a definite privilege and an honour.

I had a great morning with 85 post-graduate students, from a very wide range of nations including China and Hong Kong, South Korea, Thailand, Vietnam, Cambodia, Tanzania, Gambia, Nigeria, Lebanon, Palestine, Egypt, Malawi, Mauritius, Sri Lanka, India, Pakistan, Ecuador, Peru, Latvia, and even from here in Sweden. (My apologies to those who represent countries I may have left out). Many are women. And all are exceptional.

All have been chosen by their governments, companies, and organizations to do the courses in advanced marine management. I was invited to compliment the academic with a healthy dose of leadership training. Rather tahn adopting a command-control or technical model I talked on Authentic Leadership. We had a blast.

I am very grateful to academic dean, Prof. Patrick Donner, and to all his students, for their efforts. Honestly this is why I work: to have so many people from so many nations on one site like the World Maritime University is a wonderful opportunity to talk about what leadership is becoming and how we achieve changes that will improve both work and life in the modern world.

You may think that you’re a pretty positive person. But we’re betting no matter how hard you try, you wouldn’t be able to out-happy Matthieu Ricard, a French Buddhist monk who’s been nicknamed “the happiest man on earth.”

Seem like a stretch? We’re not just claiming that title based on the fact that Ricard is never seen without a smile, or that monks are generally a pretty beatific bunch – he’s got science on his side, too. In 2004, researchers at University of Wisconsin conducted a study on the brain patterns of hundreds of volunteers from different walks of life. The bell curve of the MRI measurements fell between +0.3 (a Sylvia Plath acolyte, no doubt) to -0.3 (Richard Simmons, perhaps?). But Ricard alone achieved an astonishing score of -0.45 – a level of joy so far above the others that his score was nearly off the chart.

So how did Ricard become the world’s happiest man? The 60-year-old monk didn’t always live a quiet life in the Himalayan mountains – as a young man, he was lauded as one of the world’s most promising biologists. But in 1972, he dropped out of the stressful world of French academia, trading in his laboratory for a monastery in Darjeeling, India, where he studied under Tibetan master Kangyur Rinpoche. In the years since, he has become well known as an author and photographer, and he serves as the Dalai Lama’s personal translator in France. He has devoted his life to the study of Buddhist philosophy and the art of happiness – and he firmly believes that the rest of us can achieve his incredible level of joy, too.

“The mind is malleable,” Ricard told The Independent. “Our life can be greatly transformed by even a minimal change in how we manage our thoughts and perceive and interpret the world. Happiness is a skill. It requires effort and time.”

To fill your life with joy, he said, you must recognize what already makes you happy, and work to change your mental balance. “You have to identify what it is in that situation that makes you happy. It’s as though you’re making a journey, and you look in your rucksack to find it half filled with provisions, half with stones. You need to take out the stones and put in more provisions.”

In his new book, Happiness, Ricard serves as your own personal cross-trainer in the art of happiness, with advice on meditative exercises to increase peace of mind, and his own philosophies on how to fill your life with joy. With his help, you might just be able to tune out your noisy neighbor’s Metallica cover band for a few minutes, and imagine you’re relaxing on a private beach instead. If you can’t make it out to visit a Buddhist monastery any time soon, his book might just be the relief you need.

<a href=http://www.ted.com/index.php/talks/view/id/191>Here</a> is video of Ricard speaking at the 2004 TED conference.

 Wynton Marsalis with the Lincoln Jazz Orchestra, De Bijloke, Ghent
Source:  Flickr (Creative Commons License)

A pair of Johns Hopkins and government scientists have discovered that when jazz musicians improvise, their brains turn off areas linked to self-censoring and inhibition, and turn on those that let self-expression flow.

This keyboard was specially designed for a study to assess brain activity in jazz musicians during improvisation. Because fMRI uses powerful magnets, the researchers designed the unconventional keyboard with no iron-containing metal parts that the magnets could attract.

The joint research, using functional magnetic resonance imaging, or fMRI, and musician volunteers from the Johns Hopkins University’s Peabody Institute, sheds light on the creative improvisation that artists and non-artists use in everyday life, the investigators say.

It appears, they conclude, that jazz musicians create their unique improvised riffs by turning off inhibition and turning up creativity.

In a report published Feb. 27 in Public Library of Science (PLoS) ONE, the scientists from the University’s School of Medicine and the National Institute on Deafness and Other Communications Disorders describe their curiosity about the possible neurological underpinnings of the almost trance-like state jazz artists enter during spontaneous improvisation.

“When jazz musicians improvise, they often play with eyes closed in a distinctive, personal style that transcends traditional rules of melody and rhythm,” says Charles J. Limb, M.D., assistant professor in the Department of Otolaryngology-Head and Neck Surgery at the Johns Hopkins School of Medicine and a trained jazz saxophonist himself. “It’s a remarkable frame of mind,” he adds, “during which, all of a sudden, the musician is generating music that has never been heard, thought, practiced or played before. What comes out is completely spontaneous.”

Though many recent studies have focused on understanding what parts of a person’s brain are active when listening to music, Limb says few have delved into brain activity while music is being spontaneously composed.

Curious about his own “brain on jazz,” he and a colleague, Allen R. Braun, M.D., of NIDCD, devised a plan to view in real time the brain functions of musicians improvising.

For the study, they recruited six trained jazz pianists, three from the Peabody Institute, a music conservatory where Limb holds a joint faculty appointment. Other volunteers learned about the study by word of mouth through the local jazz community.

The researchers designed a special keyboard to allow the pianists to play inside a functional magnetic resonance imaging (fMRI) machine, a brain-scanner that illuminates areas of the brain responding to various stimuli, identifying which areas are active while a person is involved in some mental task, for example.

Because fMRI uses powerful magnets, the researchers designed the unconventional keyboard with no iron-containing metal parts that the magnet could attract. They also used fMRI-compatible headphones that would allow musicians to hear the music they generate while they’re playing it.

Each musician first took part in four different exercises designed to separate out the brain activity involved in playing simple memorized piano pieces and activity while improvising their music. While lying in the fMRI machine with the special keyboard propped on their laps, the pianists all began by playing the C-major scale, a well-memorized order of notes that every beginner learns. With the sound of a metronome playing over the headphones, the musicians were instructed to play the scale, making sure that each volunteer played the same notes with the same timing.

In the second exercise, the pianists were asked to improvise in time with the metronome. They were asked to use quarter notes on the C-major scale, but could play any of these notes that they wanted.

Next, the musicians were asked to play an original blues melody that they all memorized in advance, while a recorded jazz quartet that complemented the tune played in the background. In the last exercise, the musicians were told to improvise their own tunes with the same recorded jazz quartet.

Limb and Braun then analyzed the brain scans. Since the brain areas activated during memorized playing are parts that tend to be active during any kind of piano playing, the researchers subtracted those images from ones taken during improvisation. Left only with brain activity unique to improvisation, the scientists saw strikingly similar patterns, regardless of whether the musicians were doing simple improvisation on the C-major scale or playing more complex tunes with the jazz quartet.

The scientists found that a region of the brain known as the dorsolateral prefrontal cortex, a broad portion of the front of the brain that extends to the sides, showed a slowdown in activity during improvisation. This area has been linked to planned actions and self-censoring, such as carefully deciding what words you might say at a job interview. Shutting down this area could lead to lowered inhibitions, Limb suggests.

The researchers also saw increased activity in the medial prefrontal cortex, which sits in the center of the brain’s frontal lobe. This area has been linked with self-expression and activities that convey individuality, such as telling a story about yourself.

“Jazz is often described as being an extremely individualistic art form. You can figure out which jazz musician is playing because one person’s improvisation sounds only like him or her,” says Limb. “What we think is happening is when you’re telling your own musical story, you’re shutting down impulses that might impede the flow of novel ideas.”

Limb notes that this type of brain activity may also be present during other types of improvisational behavior that are integral parts of life for artists and non-artists alike. For example, he notes, people are continually improvising words in conversations and improvising solutions to problems on the spot. “Without this type of creativity, humans wouldn’t have advanced as a species. It’s an integral part of who we are,” Limb says.

He and Braun plan to use similar techniques to see whether the improvisational brain activity they identified matches that in other types of artists, such as poets or visual artists, as well as non-artists asked to improvise.

This research was funded by the Division of Intramural Research, National Institute on Deafness and Other Communication Disorders, National Institutes of Health.

For additional information, go to:
http://hopkinsmedicine.org/otolaryngology/limb.html
http://www.hopkinsmedicine.org/otolaryngology/
http://www.peabody.jhu.edu/
http://www.peabody.jhu.edu/jazz

Day Two: Expectations And Realities - Getting To Grounded Work

Having seen on Day One that psychology could be applied successfully in organizations, today I want to look at a couple of the biggest movements in work psychology that arose out of work psychology rather than management thinking.

The first led to the OD movement, Organization Development began with action. Two types of action: Action Research and Action Learning. In a sentence both emphasize self-awareness as the key to organizations developing a strategic edge over the competition and to sustained growth and the strength to cope with change and when things go wrong.

Kurt Lewin [1890 - 1947]

Action Research was the child of one of the most brilliant minds ever in psychology, Kurt Lewin. Lewin was simply a brilliant mind, and a very good scientist. Many attribute the growth and impetus of social psychology and organizational psychology to him, and he influenced many outside of his specialist areas with his ideas and thinking.

The most famous example being his work on genidentity, also known as counterpart theory, that looks a the commonality between physics and biology to explain how objects arrive to be as they are - and whether they remain the same when the original materials are gone - for example, new cells in the human body, or the famous logic puzzle of the Ship of Thesus, where all parts of the ship are replaced - is it still the same ship? Fpr physicists these are important questions. It was no doubt this line of thought that seems to have turned Lewin from being a behavorist to a gestalt psychologist.

Behavorism initally looks very promising in psychology. It was, by far, the most influential movement in lab and experimental psychology in the early parts of the twentieth century, especially in America. Behavorism relies on scientific evidence, observation, and denies subjective experience. It you can’t produce the same result again it ain’t valid.

The only problem with this is that much of what psychology deals with: why do we think about things differently, what is the mind, why do we make decisions differently etc; are subjective.

Franz Brentano [1838 - 1917]

This gave rise to the Gestalt school in Berlin with its roots in Franz Brentano’s very influential lectures in Vienna from 1874 - 1895. Among Brentano’s circle that he is known to have directly influence include his most famous student Sigmund Freud, as well as the founder of anthroposophy Rudolph Steiner, the originator of the phemenology school, Edmund Husserl, which stated that all we know about the world is how our mind’s experience them, and the originator of the idea of the Gestalt, Christian von Ehrenfels. Bretano’s idea that the relation between the mind and the outside world is the relationship of the human condition was a hugely influential one.

Christian Von Ehrenfels [1859 - 1932]

Von Ehrenfels’ idea of the gestalt, along with Husserl phenomenology, found a champion of his cause in Max Wertheimer with is two of his colleagues Wolfgang Köhler and Kurt Koffka at the University of Frankfurt in 1912. Wertheimer began by looking at the phenomenon of human sight and light and kept wondering how we are able to piece together images from patterns rather than the whole.

Max Wertheimer [1880 - 1943]

These three went on to establish the Gestalt movement in Berlin. (Not to be confused with gestalt therapy also called empty chair therapy.) Wertheimer has read Ehrenfels’ work where the term gestalt (Literally: form) was coined to mean that sum of the whole is not only greater than its parts, but is also not simply put together in sequence, like say a computer, but rather arises organically from all directions. While juxtaposed to this, but in conjunction, structure does make up wholeness. It was influential thinking that and eventually would lead to cognitive psychology replacing behavorism..

In his own words:

“The basic thesis of gestalt theory might be formulated thus: there are contexts in which what is happening in the whole cannot be deduced from the characteristics of the separate pieces, but conversely; what happens to a part of the whole is, in clearcut cases, determined by the laws of the inner structure of its whole.”
Social Research, 11 (translation of lecture at the Kant Society, Berlin, 1924).

Gestalt was obviously a pretty useful way to think about how the mind and brain work. It was also a way to think about synergy and our social interactions in groups and organizations as surely the whole idea of the effect of an organization is to achieve something greater than the sum of the parts. It is also very sueful in problem solving as it asks who the parts relate to the whole, and how the whole relates to the parts; it also considers the gaps to be important

So back to Kurt Lewin.

Lewin had begun as a behavorist, but found in Gestalt what he had been missing: why groups work. He argued that group work should be better than it was, that group work should produce results, and that with self-awareness the group should get better and better at what they do.

Lewin began by looking at what stops us achieving our goals. He developed the idea and called it force field analysis. Asking what forces were stopping or helping us to go from our current state to our desired state helped groups to see the invisible problems more clearly - but identifying the problems alone wasn’t enough.

Lewin had the gumption to ask what about the people themselves? Aren’t we as often as not ourselves responsible for creating the force fields, for putting barriers in the way and making life difficult for the group?

Here, force field analysis helped, but the fact remained that though we see the fault in others easily we are slow to acknowledge it in ourselves.

The issue is not just how to tell someone what they need to do to change, or even get them to listen and understand that, the problem is to keep working with them effectively afterwards.

So Action Research.

Action research is a way of framing group work that allows people to create a learning environment, or in Lewin’s phrase a “community of practice”, it is both problem solving and a strategical tool that allows organizations to become more self-aware.

How does it work?

Well, it works on a learning loop. Loops are common in quality: plan, act, check, re-evaluate, we learn as we’re doing. They range from a simple plan-check-do cycle to more advanced cycles like Six Sigma and OODA loops. The latter helped fighter pilots to predict likely behavior of enemy pilots in Vietnam, six sigma developed by motorola reduces error to six parts or less in a million, handy in manufacturing.

Lewin coined the term feedback from electrical engineering to mean constructive criticism. More than that though action research is about building a non-judgemental culture in an organization where people genuinely listen to each other rather than simply pushing their viewpoint.

From the IDEAS site

Let us now cross the Atlantic to Britain.

And Reg Revans.

Reg Revans [1907 - 2003]

Revans was originally an astrophysicist studying with both Rutherford and Thompson at the Cavendish Laboratories at Cambridge University. I am lucky enough to have met those who knew Revans well, and the most common trait I have heard is that he was genuinely a humble man. He chose to leave his work in Cambridge to move instead to the Essex education board as he was convinced that he was an educator. He went on to beome the director of education between 1945-1950 of one of Britain’s largest employees: the National Coal Board.

While there he developed his ideas around Action Learning.

He developed a simple formula to express why people don’t succeed at work, and what they needed to do to remedy that:

L = P + Q

L is for learning. P = programmed knowledge (What we have been taught) and Q is for insightful questioning. So learning is a combination of knowledge and good questions. There are four major questions Who? Where? What? When? which should cover most aspects of the Q part of the equation.

Revans’ and Lewin’s point is entirely valid: we would rather damage our relationships in an organization rather than use some simple tools to acquire the wherewithal to learn how to genuinely learn and develop that organization effectively.

While it helps to have a practioner as an impartial facilitator the point is to find the heart and willingness to genuinely learn from each other. Management philosophy has picked up on this as we move more and more away from command and control structures to praticipative work.

Work psychology seeks to bring out the best in the organization, and Lewin and Revans both spent their lives dedicated to the idea that work should not be grey, crushing, or boring.

The other major point of the Action schools is that it moved work psychology into the workplace as a strategic tool to help individuals and companies develop strategies for excellence.

Day Three: Moving Beyond Humanistic Psychologies To The Modern Workplace

“We work for 45 years, we work more than we are in any other relationship. You’ll see the people you work with more than you’ll see your children, partners, or anybody else. We work more than we sleep, eat, or any other human activity.

When we are 45 years old, we have worked for 20 years already, and yet we are only half-way through work with another 20 years ahead of us. How can we keep going? What gives us long-term motivation? What will keep us going? What will stop work being grey? Crushing? Boring?”

From “The Way of Intelegance” seminar introduction.

Hi, and welcome to the new course from Business Intelegant. Spread over 5 days (With an occassional break of a day or two when work gets busy for me), this course looks at some of the main types and tools used in one of the most interesting ways to answer that quote above: work psychology.

Work psychology, also called organizational psychology or I/O - Industrial / Organizational psychology is more than simply testing and evaluating candidates, or helping HR to design good job descriptions.

It’s even more than the strategic implementation of HR, the building and fostering of culture within organizations, and the research and practical tools and work design that aim to make work better.

It’s also been for a hundred years one of the most fertile grounds for reaping new ideas about what work can be - how work can help evolve new societies, how work can be creative, sustaining, and promote integrity and drive, rather than work as grey, boring, crushing and just plain yuk.

Scientists and thinkers like Kurt Lewin, Elton Mayo, Reg Revans, Rensis Likert, Chris Agyris, Peter Senge, Margaret Wheatley, and Otto Scharmer. We will talk about the theories that have driven the field in leadership, organization development, and new thinking and look at theories like Action Research, Action Learning, Organization Development, Force Field Analysis, 360° Feedback, Emotional Intelligence, Theory U, to names a few, and hopefully they’ll all be done is an Intelegant fashion -which aims for simple, intelligent, elegant approaches.

We will also look at work psychology as a academic and practical scientific discipline. It is only a slight exaggeration to say if ts human and works then it has been the subject of a paper: from induction to entrepreneurial leadership, to the interaction of work and family, to promotion, discipline, and reward, onto retirement and beyond all aspects of human behaviour at work is constantly under study.

Above all work psychology is about helping us to make work a better experience through a clearer understanding of the what work is. Ideally work should be a good experience - and a profitable one, for sure - and one that feeds and nourishes the other parts of our lives without dominating it.

I believe the more we learn about work the better work becomes. It doesn’t matter what you work with, the basic tenets that make all work workable, and the job a success, nearly always apply.

I hope you will join me on this journey and that work becomes more interesting - no matter what your aims are - as a result.

Day Four: Neurotransmitters and Cognitive Strategies

So far we have looked at the biology of stress. The hormones, and physical effects of stress. On day three we looked at emotions. Today we will look a tthe neuroscience of motivation and some tools associated with cognitive psychology that are beneficial.

I remember one of the biggest surprises for me when I began learning about the brain was that there is a physical center of motivation in the brain. While this now seems entirely logical, I had imagined it was all psychological, if the will and I wanted to then I would motivate myself.

Not so.

We need to start with an overview of neurotransmitters.

Neurotransmitters are the chemical powerhouse of the brain. Made from amino acids synthesized from the proteins found in food intake. The two crucial amino acids are tryptophan and tyrosine. Tryptophan helps us feel calm, tyrosine helps us feel alert. Converted into neurotransmitters, they enable the brain’s neurons to fire. Different neurotransmitters perform different tasks. Though some 100 neurotransmitters have been identified, for our purposes we will focus on the four most common ones.

The first we’ll look at is the one most affected by stress: dopamine. Dopamine is responsible for us feeling active , lively, having a good immune response to disease, sexual arousal, and helps us face up to, and feel prepared for challenges. It is also responsible for a feeling of reward, and finally and significantly, it is, in part responsible, for addictive behaviour when it comes to drugs and alcohol. Without dopamine not only do we feel physically sluggish, we also start to lose attentiveness. Diet plays a crucial part in all neurotransmitters’ synthesis. Dopamine likes fresh fruit, and dislikes alcohol, and caffeine.

The second: serotonin. Serotonin makes us feel calm, promotes normal sleep, keeps blood pressure normal, promotes learning, and helps memory. Lack of serotonin disrupts sleep, makes us aggressive, and can lead to obssesive-compulsive eating disorders. Serotonin is the tryptophan neurotransmitter. Foods that help include brown rice and cottage cheese, as well as meat, and cheeses.

Thrirdly, norepephrine. Also called norandrenalin. Synthesized from tyrosine it is the brain’s andrenaline, and helps us feel alert. It plays an important part in memory. Foods that help include fruits and nuts, especially bananas, alsmonds, and pumpkin and sesame seeds.

And fourthly, acetylcholine. Acetylcholine (ACh) is essential for memory. It is not made from amino acids but from choline. Choline, discovered by Andreas Strecker in 1864, is an organic compound, noramlly classified with the vitamin B group. ACh is essential for brain plasticity - the ability to adapt, grow, and change, and helps the brain concentrate. Supplements of vitamin B5, C, and phosphstidyl choline all help ACh.

Obviously, one of the most under-rated keys to reducing stress is a good diet. This couple with exercise, and good cognitive strategies dramatically help us to reduce stress.

This brings us to cognitive strategies. I want in particular to look at Appreciative Inquiry (AI).

AI and Appreciative systems are used in organization development to find the positive values of the organization. Essentially it asks “What do we do well?”, rather than focusing on mistakes. Handled well it is a very powerful lever to produce real change in organizations.

M ixing AI and cognitive behavioural therapy (CBT) can be applied in a coaching model. CBT asks “Why do you think and act they way you do?”

Challenging ourselves to say “How can we do more of what we do well?” is powerful. Complementing the positive psychology of Seligman, and developed by David Cooperider, AI asked a fundamentally important question “Why do we focus our energies on what goes wrong, rather than what is right?”

We might well ask the same in medicine: how do we develop the good habits that produce a healthier brain and body.

Final Day: Conclusions And A Strategy For Stress

Friday, Jan. 25, 2008. Rush Medical Center, Chicago - neurosurgeon, Demetrius Lopes, holds up a Penumbra stroke vacuum system.

This is a tiny vacuum cleaner for the brain, and is the newest treatment for stroke victims, promising to literally suction out clogged arteries to get blood flowing again.

Now the question is how to tell which patients are good candidates for the proceedure? As illogical as it may sound, unclogging isn’t always the best option to treat strokes, due to systolic and diastolic pressure and so bloodflow in sensitive areas. Strokes remain the No. 3 killer in the US and the UK.

(AP Photo/Jerry Lai)